Diabetes Res Clin Pract 1991;14:191-5. 2000;2(2):189-193. Jing, L., Li, W. M., Zhou, L. J., and Song, J. However, several studies note mild benefits associated with larger or more long-term doses (43, 44, 45). View abstract. Propionyl-L-Carnitine - RxList Therapeutic Research Faculty 2018. Disclaimer: Go To See My Account. J Trop.Pediatr. Oral administration of l-carnitine improves the clinical outcome of fertility in patients with IVF treatment. J Pediatr 1982;101:782-5. L-Carnosine: Benefits, Side Effects & Dosage - BulkSupplements.com China Tropical Med 2007;7(5):753-754. In one study, people who took 3 grams every day for 21 days experienced no negative effects (57). J Androl 2004;25(5):761-770. Clin Nutr ESPEN 2021;46:54-59. Bohmer, T., Boen, A., and Hoymork, S. C. Valproate-induced hyperammonemic encephalopathy, rapidly improved by i.v. View abstract. Brevetti G, Diehm C, Lambert D, et al. Kahn J, Lagakos S, Wulfsohn M, et al. McMackin, C. J., Widlansky, M. E., Hamburg, N. M., Huang, A. L., Weller, S., Holbrook, M., Gokce, N., Hagen, T. M., Keaney, J. F., Jr., and Vita, J. Brass, E. P., Hoppel, C. L., and Hiatt, W. R. Effect of intravenous L-carnitine on carnitine homeostasis and fuel metabolism during exercise in humans. Cardiology 2006;106(4):215-223. Hiraoka A, Kiguchi D, Ninomiya T, et al. Long-Term Levocarnitine Ameliorates Left Ventricular Diastolic as Well as Systolic Dysfunction in Hemodialysis Patients - Multi-Center Study. New Trends Clin Neuropharmacol 1989;3(1):17-24. O'Donnell, J., Finer, N. N., Rich, W., Barshop, B. View abstract. Lynch, K. E., Feldman, H. I., Berlin, J. J Androl 2012;33(2):170-175. View abstract. Pucciarelli, G., Mastursi, M., Latte, S., Sacra, C., Setaro, A., Lizzadro, A., and Nolfe, G. [The clinical and hemodynamic effects of propionyl-L-carnitine in the treatment of congestive heart failure]. BMC Public Health. View abstract. Evidence suggests it may promote weight loss by increasing calorie expenditure.6. Orlando G and Rusconi C. Oral L-carnitine in the treatment of chronic cardiac ischaemia in elderly patients. View abstract. View abstract. Lebrun C, Alchaar H, Candito M, et al. A., Kraemer, W. J., Vingren, J. L., Hatfield, D. L., Fragala, M. S., Ho, J. Y., Maresh, C. M., Anderson, J. M., and Volek, J. S. Responses of criterion variables to different supplemental doses of L-carnitine L-tartrate. In a 90-day study, people with alcohol addictions who took 2 grams of acetyl-L-carnitine per day experienced significant improvements in all measures of brain function (38). Eur J Appl Physiol Occup.Physiol 1987;56(4):457-460. 1988;26(5):269-272. 2006;12(5):261-262. Carnitor (levocarnitine)." Pediatr.Res 1982;16(2):89-91. Eur J Urol 1996;30(Suppl 2):954. 12-3-1999;87(4):366-368. Eur J Appl Physiol Occup.Physiol 1990;60(1):1-6. L-Carnosine - Nootropics Expert Swart I, Rossouw J, Loots JM, and et al. Hooshmand, S., Balakrishnan, A., Clark, R. M., Owen, K. Q., Koo, S. I., and Arjmandi, B. H. Dietary l-carnitine supplementation improves bone mineral density by suppressing bone turnover in aged ovariectomized rats. Bradycardia treatment depends on the underlying cause of the low resting heart rate but may also include the surgical placement of a pacemaker. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to levocarnitine: injectable solution, oral capsule, oral solution, oral tablet. Clin Ther 2003;25(5):1429-1439. Eidi, M., Pouyan, O., Shahmohammadi, P., Saeidi, H., Bahar, M., and Eidi, A. Low Blood Pressure. View abstract. Physiologie. Effects of propionyl-L-carnitine on peripheral arterial obliterative disease of the lower limbs: a double-blind clinical trial. Zhang X, Cui Y, Dong L, Sun M, Zhang Y. View abstract. Neurochem.Res. Effects of L-carnitine administration on VO2max and the aerobic- anaerobic threshold in normoxia and acute hypoxia. Merchant, R., Jain, A., Udani, A., Puri, V., and Kotian, M. L-carnitine in beta thalassemia. It can cause nausea, abdominal cramps, vomiting, and diarrhea when taken in high doses. View abstract. Anti-human immunodeficiency virus (HIV) activitiy, safety, and pharmacokinetics of adefovir dipivoxyl (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients. View abstract. I take alpha lipoic acid and acetyl L carnitine twice a day, everyday. L-carnitine is also linked to improvements in patients with severe heart disorders, such as coronary heart disease and chronic heart failure (40, 41). Herrmann, W. M., Dietrich, B., and Hiersemenzel, R. Pharmaco-electroencephalographic and clinical effects of the cholinergic substance--acetyl-L-carnitine--in patients with organic brain syndrome. View abstract. Chan, A., Remington, R., Kotyla, E., Lepore, A., Zemianek, J., and Shea, T. B. Calandrella, N., De, Seta C., Scarsella, G., and Risuleo, G. Carnitine reduces the lipoperoxidative damage of the membrane and apoptosis after induction of cell stress in experimental glaucoma. Rockstar Energy, an energy drink company, produces Rockstar Zero Carb as well as several other Rockstar flavours. View abstract. 2002;4(1):61-66. View abstract. View abstract. View abstract. View abstract. 2008;25(8):734-743. 2006;115(1-2):91-96. Nutrients 2020;12(11):3371. Plioplys AV, Plioplys S. Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome. View abstract. View abstract. Minerva Urol.Nefrol. . J Inherit.Metab Dis 2006;29(2-3):288-298. J Pediatr Gastroenterol Nutr 1985;4(5):795-798. Mantovani G, Maccio A, Madeddu C, et al. Carnitine metabolism in early stages of Duchenne muscular dystrophy. In children, L-carnitine has most often been used in doses of 50-100 mg/kg by mouth daily, for up to one year. Int J Curr Res Acad Rev 2015;3:469-76. Mingrone G, Greco AV, Capristo E, et al. L-carnitine supplementation for the management of fatigue in patients with hypothyroidism on levothyroxine treatment: a randomized, double-blind, placebo-controlled trial. Adefovir dipivoxil. View abstract. L-carnitine supplementation in childhood epilepsy: Current perspectives. L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial. Abbasnezhad A, Hasanavand A, Falahi E, Kashkooli S, Asbaghi O, Choghakhori R. Effect of L-carnitine supplementation on lipid profiles of patients with liver disease: a systematic review and meta-analysis. Thomsen, J. H., Shug, A. L., Yap, V. U., Patel, A. K., Karras, T. J., and DeFelice, S. L. Improved pacing tolerance of the ischemic human myocardium after administration of carnitine. 2007;9(4):249-255. View abstract. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Energy Drinks | Healthy Schools | CDC Kidney Int 38 (1990): 904-11, 4. Nutr J. Drugs Exp Clin Res 1999;25:167-71. Cochrane.Database.Syst.Rev. View abstract. Additional L-carnitine Reduced the Risk of Hospitalization in Patients with Overt Hepatic Encephalopathy on Rifaximin. I fell asleep at night but woke up repeatedly and then couldn't get back to sleep. Pediatr Res 1984;18:815-9. Pharmacol Res 1998;37(2):115-122. The effect of L-carnitine supplementation on plasma carnitine levels and various performance parameters of male marathon athletes. What's L-Carnitine, and Does It Live Up to the Hype? - Greatist It seems l carnitine is a relatively safe nutrient in doses ranging from 50 to 500 mg. Higher doses may lead to excess energy, restlessness, perhaps insomnia. We comply with the HONcode standard for trustworthy health information. Drug class: Nutraceutical products. Revista Latina De Cardiologia - Euroamericana 1997;18(2):25-30. Nasca D, Zurria G, and Aguglia E. Action of acetyl-L-carnitine in association with mianserine on depressed old people. Fornasini, G., Upton, R. N., and Evans, A. M. A pharmacokinetic model for L-carnitine in patients receiving haemodialysis. View abstract. View abstract. View abstract. Rossini, M., Di, Munno O., Valentini, G., Bianchi, G., Biasi, G., Cacace, E., Malesci, D., La, Montagna G., Viapiana, O., and Adami, S. Double-blind, multicenter trial comparing acetyl l-carnitine with placebo in the treatment of fibromyalgia patients. Diabetes Care 2005;28:89-94. Influence of L-carnitine intake. Eur.J Clin.Nutr. View abstract. View abstract. View abstract. Effects of Carnitine on Thyroid Health - Thyroid Advisor Zhu Y, Xue C, Ou J, Xie Z, Deng J. According to this work, published online in the journal Nature Medicine, eating red meat delivers L-carnitine to bacteria that live in the human gut. 2006;114(1):1-7. View abstract. Reduce dosage to alleviate this side effect. 2011;(12):CD006282. View abstract. Baghban F, Hosseinzadeh M, Mozaffari-Khosravi H, Dehghan A, Fallahzadeh H. The effect of L-Carnitine supplementation on clinical symptoms, C-reactive protein and malondialdehyde in obese women with knee osteoarthritis: a double blind randomized controlled trial. Changes in lipid pattern. Naturally produced in the body, acetyl-L-carnitine is also widely available in drugstores, supermarkets and health food catalogs as a . Effects of parenteral L-carnitine supplementation on fat metabolism and nutrition in premature neonates. Sotobatake I, Noda S, Hayashi H, and et al. Applies to levocarnitine: capsule, capsule liquid filled, solution, tablet. If you do not have a dose-measuring device, ask your pharmacist for one. Impact of L-carnitine on plasma lipoprotein(a) concentrations: A systematic review and meta-analysis of randomized controlled trials. Heller, W., Musil, H. E., Gaebel, G., Hempel, V., Krug, W., and Kohn, H. J. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. View abstract. Brand names: Carnitor, L-Carnitine Bohles H, Noppeney T, Akcetin Z, and et al. View abstract. [RETRACTED]. Insomnia, headaches and vertigo are common side effects. Bellinghieri G, Savica V, Barbera CM, Ricciardi B, Egitto M, Torre F, Valentini G, D'Iddio S, Bagiella E, Mallamace A, et al. View abstract. J Strength.Cond.Res. Serum carnitine levels in epileptic children before and during treatment with valproic acid, carbamazepine, and phenobarbital. 2006;35(2):158-161. Brain Dev. View abstract. J Child Neurol 1999;14:162-7. Acta Anaesthesiol.Scand. Raskind JY, El-Chaar GM. Cacciatore L, Cerio R, Ciarimboli M, et al. Carnosine is found throughout your body. Benedini, S., Perseghin, G., Terruzzi, I., Scifo, P., Invernizzi, P. L., Del, Maschio A., Lazzarin, A., and Luzi, L. Effect of L-acetylcarnitine on body composition in HIV-related lipodystrophy. J.Japanese Society Nutrition Food Sci 2007;60(5):257-264. View abstract. Wolfe, L. A., He, M., Vockley, J., Payne, N., Rhead, W., Hoppel, C., Spector, E., Gernert, K., and Gibson, K. M. Novel ETF dehydrogenase mutations in a patient with mild glutaric aciduria type II and complex II-III deficiency in liver and muscle. View abstract. 2014 Nov 26;13:110. You should not breast-feed while using L-Carnitine. View abstract. View abstract. View abstract. Eur J Gastroenterol Hepatol 2019;31(7):878-84. doi: 10.1097/MEG.0000000000001368. Sports Med 1996;22:109-32. View abstract. Is Acetyl-L-Carnitine Good for Your Mental Health? Gomez-Amores, L., Mate, A., Miguel-Carrasco, J. L., Jimenez, L., Jos, A., Camean, A. M., Revilla, E., Santa-Maria, C., and Vazquez, C. M. L-carnitine attenuates oxidative stress in hypertensive rats. View abstract. 2009;25(9):2223-2228. Studies concerning chronic and acute effects of L-carnitine on some biological parameters in elite athletes. HIV.Med. Lion's mane mushrooms: Benefits and side effects - Medical News Today Mondillo, S., Faglia, S., D'Aprile, N., Mangiacotti, L., Campolo, M. A., Agricola, E., and Palazzuoli, V. [Therapy of arrhythmia induced by myocardial ischemia. Goodison G, Overeem K, de Monte V, Siskind D. Mania associated with self-prescribed acetyl-l-carnitine in a man with bipolar I disorder. Iyer, R. N., Khan, A. Guan, Y., Zheng, X. M., Yang, Z. W., and Li, S. W. [Protective effects of L-carnitine upon testicular ischemia-reperfusion damage in rats]. Pola, P., Tondi, P., Flore, R., Serricchio, M., Dal Lago, A., Amanti, C., Consorti, F., Benedetti, M., and Midiri, H. Effect of l-carnitine on lipid pattern in debilitated patients treated with Intralipid. Williams, S. F., Alvarez, J. R., Pedro, H. F., and Apuzzio, J. J. Glutaric aciduria type II and narcolepsy in pregnancy. Clinical evaluation of the effects of levocarnitine chloride (LC-80) on excercise tolerance in stable angina pectoris by the serial multistage treadmill exercise testing: a multicenter, double-blind study. Castro-Gago M, Eiris-Punal J, Novo-Rodriguez MI, et al. View abstract. Nephrologie 1998;19:171. L-carnitine, ginseng, guarana, glucose, taurine, and more. You can get small amounts of L-carnitine from your diet by eating meat and fish (4, 5). L-carnitine supplementation may cause unpleasant fishy odor and suppress thyroid hormones. Gen Thorac Cardiovasc Surg 2021;69(11):1460-1466. Caponnetto S, Canale C, Masperone MA, et al. Nephron 1990;55(1):28-32. J Child Neurol 2003;18:552-4. 2006;30(5):421-425. Ann Neurol 1988;24:301. This is not a complete list of side effects and others may occur. Geier, D. A., Kern, J. K., Davis, G., King, P. G., Adams, J. Superiority of L-propionylcarnitine vs L-carnitine in improving walking capacity in patients with peripheral vascular disease: an acute, intravenous, double-blind, cross-over study. The effect of L-carnitine (carnitene) on myocardial metabolism of patients with coronary artery disease. A., Hatfield, D. L., Vingren, J. L., Quann, E. E., Anderson, J. M., Maresh, C. M., and Kraemer, W. J. Tempesta E, Troncon R, Janiri L, et al. View abstract. Chen, J. C., Tsai, T. C., Liu, C. S., and Lu, C. T. Acute hearing loss in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). View abstract. 2007;22(6):330-337. J Inherit.Metab Dis 2007;30(5):811. B., Lagler, F., Maier, E. M., Schwahn, B., Tokatli, A., Dursun, A., Coskun, T., Chalmers, R. A., Koeller, D. M., Zschocke, J., Christensen, E., Burgard, P., and Hoffmann, G. F. Natural history, outcome, and treatment efficacy in children and adults with glutaryl-CoA dehydrogenase deficiency. J Nephrol. J Am Coll Cardiol 1999;34:1618-24. Sabry, A. J Eur Acad Dermatol Venereol 1999;13:205-9. Verrina, E., Caruso, U., Calevo, M. G., Emma, F., Sorino, P., De, Palo T., Lavoratti, G., Turrini, Dertenois L., Cassanello, M., Cerone, R., and Perfumo, F. Effect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis. View abstract. Curr Ther Res 1980;27(2):208-216. Med.Sci Monit. View abstract. World J Gastroenterol. View abstract. Weigel, C., Kiener, C., Meier, N., Schmid, P., Rauh, M., Rascher, W., and Knerr, I. Carnitine status in early-treated children, adolescents and young adults with phenylketonuria on low phenylalanine diets. Diagnosis, treatment and outcome of glutaric aciduria type I in Zhejiang Province, China. Pola P, Savi M, Grilli M, and et al. Bernard, A., Rigault, C., Mazue, F., Le, Borgne F., and Demarquoy, J. L-carnitine supplementation and physical exercise restore age-associated decline in some mitochondrial functions in the rat. Med.Sci Monit. Kotby, A. Yarizadh H, Shab-Bidar S, Zamani B, Vanani AN, Baharlooi H, Djafarian K. The effect of L-carnitine supplementation on exercise-induced muscle damage: A systematic review and meta-analysis of randomized clinical trials. Am.J Alzheimers.Dis Other Demen. View abstract. Insomnia; Energy drinks can cause insomnia, especially when it . Prolonged moderate-intensity exercise without and with L-carnitine supplementation in patients with MCAD deficiency. Clinical Trials Journal 1986;23(6):338-344. Liu J, Head E, Kuratsune H, et al. View abstract. Trovato GM, Ginardi V, Di Marco V, and et al. Although potent on its own, this supplement works best when stacked with other nootropics. You may report side effects to FDA at 1-800-FDA-1088. View abstract. Here are 10 nootropic supplements proven to have brain-boosting benefits. 7 Best Creatine Supplements for Women in 2023: A Dietitians Picks. Neuropsychobiology 1997;35:16-23. View abstract. [Clinical efficacy of intravenous L-carnitine in patients with right-sided heart failure induced by pulmonary arterial hypertension]. This information may not fit your specific health circumstances. Cellular stress responses, mitostress and carnitine insufficiencies as critical determinants in aging and neurodegenerative disorders: role of hormesis and vitagenes. Bjornsson, E. Hepatotoxicity associated with antiepileptic drugs. Effect of L-carnitine on health-related quality of life in patients with liver cirrhosis. Expert.Opin.Pharmacother. View abstract. Siami, G., Clinton, M. E., Mrak, R., Griffis, J., and Stone, W. Evaluation of the effect of intravenous L-carnitine therapy on function, structure and fatty acid metabolism of skeletal muscle in patients receiving chronic hemodialysis. This study therefore aimed to examine the effect of l-carnitine supplementation on body weight and composition by including the maximum number of randomized controlled trials (RCTs) and to conduct a dose-response analysis, for the first . J Pharm Sci 1995;84(5):627-633. J Pediatr 1986;109(6):984-988. Hamedi-Kalajahi F, Zarezadeh M, Mojtahedi SY, Shabbidar S, Fahimi D, Imani H. Effect of L-carnitine supplementation on lipid profile and apolipoproteins in children on hemodialysis: a randomized placebo-controlled clinical trial. Drugs Aging 2003;20:761-7. J Infect Dis 1997;176:1517-23. Shakeri, A., Tabibi, H., and Hedayati, M. Effects of L-carnitine supplement on serum inflammatory cytokines, C-reactive protein, lipoprotein (a), and oxidative stress in hemodialysis patients with Lp (a) hyperlipoproteinemia. 2007;20(5):499-502. Tohoku J Exp.Med. Benton, D. and Donohoe, R. T. The influence on cognition of the interactions between lecithin, carnitine and carbohydrate. Sato S, Namisaki T, Furukawa M, et al. Dal Negro, R., Turco, P., Pomari, C., and De Conti, F. Effects of L-carnitine on physical performance in chronic respiratory insufficiency. Eur.J.Gen.Med 2009;6(2):7-15. View abstract. Xie, J., Zeng, Q., and Wang, L. The protective effect of L-carnitine on ischemia-reperfusion heart.